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This medication is a strong diuretic which works by way of inhibiting the reuptake of sodium at the proximal and distal tubules of the kidney, as well as the ascending limb of Henle's loop.
It’s employed in the treatment of edema (swelling), secondary to congestive heart failure, cirrhosis of the liver, and renal disease, including nephrotic syndrome. It’s also used as an adjunctive therapy in acute pulmonary edema and for the treatment of hypertension (elevated blood pressure).
This medication should not be used: in electrolyte deficiency (as in severe hypokalaemia and severe hyponatraemia); in hypovolaemia, dehydration, and renal failure due to nephrotoxic or hepatotoxic agents; in renal failure in conjunction with hepatic coma; in pre-comatose and comatose states secondary to hepatic encephalopathy/liver cirrhosis; in patients with anuria, or renal failure with anuria that do not have a proper response to furosemide.
Reported side effects include: hepatic encephalopathy in patients with hepatocellular insufficiency; severe anaphylactic or anaphylactoid reactions (for example, in patients with shock); tinnitus (ear ringing) and hearing loss; aplastic anemia, exfoliative dermatitis and hyperglycemia.
Teva Pharmaceutical Industries Ltd, Israel
Also known as: Furosemide, Lasix, Furon, Diurmessel, Frusenex, Edemid, Biomisen