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Diane 35 (Cyproterone acetate 2 mg, Ethinylestradiol 0.035 mg) 21 tabl



Treatment of acne

Diane-35 contains a pair of sex hormones – cyproterone acetate and ethinyl estradiol, which are in a certain ratio.

Each Diane-35 tablet contains 2 mg of cyproterone acetate and 0.035 mg of ethinyl estradiol.

Excipients contained in Diane-35 are: calcium carbonate, iron oxide yellow, corn starch, glycerin, lactose, magnesium stearate, povidone, sucrose, polyethylene glycol (macrogol), titanium dioxide, talc and wax.

21 tablets

Manufacturer: Bayer AG

Indications and clinical use

Diane-35 (cyproterone acetate and ethinyl estradiol) is intended for women treating extensive acne with concomitant symptoms of androgenization, including seborrhea and moderate hirsutism.

The medication should be used only in cases when acne is not treated with local therapy and an oral antibiotic course.


Do not take the drug in the following cases:

  • cerebrovascular disorders - existing or in history;
  • myocardial infarction or coronary artery disorders - existing or in history;
  • active liver diseases;
  • liver tumors (benign and malignant) - existing or in history;
  • thrombophlebitis or thromboembolic diseases - existing or in history;
  • cholestatic jaundice in anamnesis;
  • in case of severe diabetes accompanied by vascular disorders;
  • confirmed or suspected carcinoma of the breast;
  • diagnosed or suspected estrogen-dependent neoplasm;
  • unusual vaginal bleeding of unknown etiology;
  • any vision pathology resulting from the eye vessels diseases, for example, partial or complete loss of vision or visual field disturbance;
  • simultaneous reception of other estrogen and progesterone combinations or a separate intake of estrogen/progesterone preparations;
  • in case of suspected or confirmed pregnancy;
  • suspected or confirmed hypersensitivity to any component of Diane-35.

Adverse reactions

The increased risk of these serious side effects is associated with the intake of estrogen and progesterone combinations:

  • thrombophlebitis;
  • arterial thromboembolism;
  • pulmonary embolism;
  • thrombosis of the mesenteric vessels;
  • neuro-ophthalmologic disorders (e.g., retinal vein thrombosis and optic neuritis);
  • myocardial infarction;
  • heart stroke;
  • hemorrhagic stroke;
  • hypertension;
  • liver tumors;
  • gallbladder diseases;
  • congenital malformations.

Known as: Estelle-35, Chloe, Bellune 35


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