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Used in oncology
Active ingredient - Anastrozole
Manufacturer - Perrigo Israel Pharmaceuticals, Israel.
Adjuvant treatment of early breast gormon-positive women cancer in postmenopausal period; treatment of advanced breast women cancer in postmenopausal period; adjuvant therapy of early breast women cancer gormon-positive in postmenopausal period after tamoxifen therapy for 2-3 years.
Hypersensitivity; premenopause period; concomitant therapy with tamoxifen or drugs containing estrogen; severe renal impairment (creatinine clearance).
It is not allowed Anastrozole medication for pregnant women and during lactation period.
Estrogen and tamoxifen reduced pharmacological effect of Anastrozole.
In the presence of women receptor-negative estrogen tumor Anastrozole does not demonstrate efficiency, except of cases of a positive therapeutic response to tamoxifen. It is necessary to confirm menopause by blood definition of sex hormones to clearly define women hormonal status.
If there is utering bleeding at the time of Anastrozole medication - patient need to consult a gynecologist.
As Anastrozole lowers estradiol levels, it may cause decrease bone mineral density. So, if there is osteoporosis or its development, it is necessary to densitometry measure by bone density in the start of treatment and during it. It is necessary to refuse perform activities requiring precision reactions during Anastrozole medication.
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