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Antiemetic, appointed with chemotherapy.
Active ingredient - Aprepitant
EMEND in combination with other antiemetic drugs is indicated for acute prevention and delayed nausea and vomiting caused by highly and moderately emetogenic cancer therapies.
Hypersensitivity to aprepitant or to any other component of the drug.
Concomitant use with pimozide, terfenadine, astemizole and cisapride. Severe hepatic impairment (> 9 points on a scale Child-Pugh).
EMEND should be used with caution by patients concomitantly receiving warfarin and drugs that are metabolized mainly by CYP3A4. Simultaneous prescribe EMENDA with warfarin may result in a clinically significant decrease in the international normalized ratio (INR). Patients receiving long term warfarin therapy should be carefully monitored MHO level for 2 weeks at each cycle of chemotherapy, especially in 7-10 days after the beginning of EMENDA medication 3-day scheme.
The efficacy of hormonal contraceptives may be reduced during medication and within 28 days after EMENDA medication. There should use alternative methods of contraception during medication and for 1 month after the last dose of EMENDA.
EMENDA is not recommended for use during pregnancy. It is necessary to take a decision to stop feeding or withdrawal of the drug due to the potential adverse EMENDA effect on infants.
Most of sude effects, identified during clinical trials, were considered mild or moderate in intensity. Most common adverse events associated with aprepitant medication, which occurred in patients receiving the drug in accordance with the recommended scheme in Highly Emetogenic Chemotherapy, were hiccups (4.6%), weakness / fatigue (2.9%), increased ALT (2.8%), constipation ( 2.2%), headache (2.2%) and anorexia (2.0%). In accordance with the recommended scheme in moderately emetogenic chemotherapy - fatigue (2.5%).
The following are the side effects observed with the use of apripetanta on the background of anti-tumor therapy in accordance with the following frequency of occurrence: often -from> 1/100 to 1/1000 to...
Hematopoietic system: anemia, febrile neutropenia (rarely). There are often possible: headache, dizziness; rarely - sleep disorders, cognitive disorders, disorientation, euphoria, anxiety (central nervous system). Visual: rare conjunctivitis. Hearing organs: rarely buzzing. Cardiovascular system: rarely bradycardia. Respiratory system: rarely sore throat, sneezing, cough, postnasal syndrome, throat irritation. There are often possible anorexia, hiccups, constipation, diarrhea, dyspepsia, belching; rarely - nausea, acid reflux, dysgeusia, epigastric discomfort, obstipation, gastroesophageal reflux disease, perforated duodenal ulcer, abdominal pain, dry mouth, enterocolitis, flatulence, stomatitis (digestive system). Skin and skin appendages: seldom - rash, acne, increased sensitivity to light, excessive sweating, oily skin, pruritus. Musculoskeletal system: rarely muscle cramps, myalgia. Urinary system: rarely polyuria, dysuria, pollakiuria. Causes of changes in the laboratory parameters often are: increase of ALT and ACT level; rarely - increased activity of alkaline phosphatase, hyperglycemia, hyponatremia, microhematuria.
Others: often - weakness / fatigue; rarely - swelling, hot flashes ("hot flushes"), discomfort feeling in the chest, drowsiness, thirst, decrease or increase in body weight, joining a staph or fungal (candidiasis) infections.
There marked one with patient received chemotherapy aprepitant with Stevens-Johnson syndrome. In another case the use of only aprepitant experienced angioedema and urticaria. Profile of adverse events during repeated cycles of chemotherapy (up to 6) with the use of aprepitant was comparable to that during the 1st cycle of chemotherapy.
Known as: Aprecap, Aprelief, Aprepit, Apresafe, Aprikit, Aprisib, Empov, Apricyt, Aprepet-Z, Emvoid, Apriset, Apretero, Piptashil, Apreone
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