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The antineoplastic drug. AI (Aromatase Inhibitor). Treatment of breast tumors.
Active ingredient - Letrozole 2.5 mg
Manufacturer - Dexcel Pharma Technologies Ltd, ISRAEL
This drug should be taking with care if patients have deficiency of lactase, lactase intolerance and glucose-galactose malabsorption.
Generally, adverse events were mild or moderate expressed and primarily associated with inhibition of estrogen synthesis.
Digestive system disorders: often – nausea, vomiting, dyspepsia, constipation, diarrhea; sometimes – abdominal pain, stomatitis, dry mouth, increased liver enzymes.
Nervous system disorders: often – headache, dizziness, depression; sometimes – anxiety, nervousness, irritability, drowsiness, insomnia, memory impairment, dysesthesia, paresthesia, hypoesthesia, episodes of cerebrovascular accidents.
Hemopoiesis system disorders: sometimes – leukopenia.
Cardiovascular system disorders: sometimes – palpitations, tachycardia, thrombophlebitis of superficial and deep veins, increased blood pressure, ischemic heart disease (angina, myocardial infarction, heart failure), thromboembolism; rarely –pulmonary embolism, arterial thrombosis, stroke.
Respiratory system disorders: sometimes – shortness of breath, cough.
Dermatological reactions: often – alopecia, increased sweating, rash (including erythematous, maculo-papular, vesicular rash, psoriasiform rash); sometimes – itching, dry skin, urticaria; very rarely – angioedema, anaphylactic reactions.
Musculoskeletal system disorders: very often – arthralgia; often – myalgia, bone pain, osteoporosis, bone fractures, sometimes – arthritis.
Sensory organs disorders: sometimes – cataract, eye irritation, blurred vision, taste disturbance.
Urinary system disorders: sometimes – frequent urination, urinary tract infection.
Reproductive system disorders: sometimes – vaginal bleeding, vaginal discharge, vaginal dryness, breast pain.
Metabolism disorders: often – increased body mass index, hypercholesterolemia, anorexia, increased appetite; sometimes – loss of weight, thirst.
Others: very often – hot flashes (flushes); often – fatigue, asthenia, malaise, peripheral edema; sometimes – hyperthermia (pyrexia), dry mucous membranes, generalized edema, pain in the tumor nidus.
Also known as: Letroz, Letrozole Tablets USP, Femara Novartis, Letronat, Trozet, Fempro, Letrozole Actavis, Let Rejun, Letoval, Letrozol, Apo-Letrozole, Letromina, Letrofem
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